New Hydroxamic Acid Derivative Prevents Sq—OOH Induced Wrinkle
نویسندگان
چکیده
منابع مشابه
A Novel Suberoylanilide Hydroxamic Acid Histone Deacetylase Inhibitor Derivative, N25, with Improved Antitumor Activity
A mass of research have demonstrated that epigenetic gene modulation has been postulated to be an essential mechanism in cancer development and metastasis (Nelson et al., 2012). The modification of histone acetylation plays a critical role in epigenetics as the hotspot of international research (Sriraksa et al., 2013). Especially in histone tails the reversible acetylation of lysine residues ha...
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PURPOSE Angiogenesis is required for tumor progression and represents a rational target for therapeutic intervention. Histone deacetylase (HDAC) inhibitors have been shown to have activity against various tumor cell types by inhibiting proliferation and inducing apoptosis both in vitro and in vivo. HDAC inhibitors have also been reported to inhibit angiogenesis. The goal of this study was to ch...
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Hydroxamic acids serve as a monsulfhydril bisubstrate analog inhibition of fernesyl protein transferase (FPT), the enzyme catalysing fernesylation of p21ras. Tumor necrosis factor (TFN) is specifically prevented by synthetic hydroxamic acid-based metalloproteinase inhibitors. Suberoyanilide hydroxamic acid (SAHA) have been identified as histone deacetylase inhibitors based on their ability to i...
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Breast cancer is one of the most common malignancies among women in the world, investigating the characteristics and special transduction pathways is important for better understanding breast development and tumorigenesis. Leptin, a peptide hormone secreted from white adipocytes, may be an independent risk factor for breast cancer.Here, we treated suberoylanilide hydroxamic acid (SAHA) on Lepti...
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We generalize the basic enhançon solution of Johnson, Peet and Polchinski [1] by constructing solutions without spherical symmetry. A careful consideration of boundary conditions at the enhançon surface indicates that the interior of the supergravity solution is still flat space in the general case. We provide some explicit analytic solutions where the enhançon locus is a prolate or oblate sphe...
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ژورنال
عنوان ژورنال: ChemInform
سال: 2006
ISSN: 0931-7597,1522-2667
DOI: 10.1002/chin.200619075